|
KMID : 0358420130560010022
|
|
Korean Journal of Obstetrics and Gynecology
2013 Volume.56 No. 1 p.22 ~ p.28
|
|
|
Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants
|
|
Yang Ga-Young
Lee Kyung-A
Park Mi-Hye
Park Hye-Sook
Ha Eun-Hee
Chun Sun-Hee
Kim Young-Ju
|
|
|
Abstract
|
|
|
|
Objective : The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants. Methods : We analyzed maternal urinary levels of nephrin in women who were normal controls (n=50), women who were delivered SGA infants (n=40), and gravidas with PE (n=33) in the first, second and third trimesters. Urinary nephrin concentrations were measured with nephrin enzyme-linked immunosorbent assay kits. Results : The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P<0.05 for both). Maternal urine concentrations of nephrin were higher in pregnancies complicated by SGA and PE in the third trimester (P<0.05), and also higher in pregnancies complicated by SGA in the first trimester (P<0.05). The sensitivity and specificity of nephrin in predicting SGA from normal pregnancies were 67% and 89% in the first trimester, 60% and 79% in the second trimester, and 80% and 84% in the third trimester, respectively. The sensitivity and specificity of nephrin in predicting PE from normal pregnancies were 67% and 83% in the first trimester and 73% and 79% in the third trimester, respectively. Conclusion : We suggest that urinary nephrin can be used as an early marker in pregnancies at risk for developing PE and SGA infants.
|
|
|
KEYWORD
|
|
|
Nephrin, Small-for-gestational age, Preeclampsia, Urine, Early marker
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|